Benedict Cumberbatch

Patrick Melrose

Jennifer Jason Leigh

Eleanor Melrose

Hugo Weaving

David Melrose

Sebastian Maltz

Young Patrick

Jessica Raine

Julia

Prasanna Puwanarajah

Johnny

Pip Torrens

Nicolas Pratt

Anna Madeley

Mary Melrose, Cousin Mary

Indira Varma

Anne Moore

Blythe Danner

Nancy Valance

Gary Beadle

Chilly Willy

Celia Imrie

Kettle

Morfydd Clark

Debbie Hickman

Holliday Grainger

Bridget Watson-Scott, Lady Gravesend

Eileen Walsh

Annette

John Standing

George Watford

Marcus Smith

Robert Melrose

Dainton Anderson

Thomas Melrose