Henry Fonda

Frank

Charles Bronson

Harmonica

Claudia Cardinale

Jill McBain

Jason Robards

Manuel 'Cheyenne' Gutiérrez

Gabriele Ferzetti

Morton

Paolo Stoppa

Sam

Woody Strode

Stony

Jack Elam

Snaky

Keenan Wynn

Sheriff

Frank Wolff

Brett McBain

Lionel Stander

Barman

Livio Andronico

Bit part

Salvatore Basile

Member of Cheyenne's Gang

Aldo Berti

Member of Frank's Gang Playing Poker

Regina Elena Bisio

Old Woman in the Tavern

Joseph Bradley

Train Station Master

Frank Braña

Member of Frank's Gang Smoking Pipe at Auction

Marilù Carteny

Mourner at Brett McBain's Funeral