Nathan Fillion

Richard Castle, Joe Flynn

Stana Katic

Kate Beckett, Vera Mulqueen

Susan Sullivan

Martha Rodgers, Florence Kennard

Jon Huertas

Javier Esposito, Dempsey's Cuban, Daniel Santos

Seamus Dever

Kevin Ryan, Dempsey's Irishman, Fenton O'Connell

Molly C. Quinn

Alexis Castle, Sally Scofield

Tamala Jones

Lanie Parish, Betsy Sinclair, Pam Hodges

Penny Johnson Jerald

Captain Victoria Gates

Ruben Santiago-Hudson

Captain Roy Montgomery

Maya Stojan

Tory Ellis